MULTIPLEXED CRISPR/CAS9-MEDIATED KNOCKOUT OF 19 FANCONI ANEMIA PATHWAY GENES IN ZEBRAFISH REVEALED THEIR ROLES IN GROWTH, SEXUAL DEVELOPMENT AND FERTILITY.

Fanconi Anemia (FA) is a genomic instability syndrome resulting in aplastic anemia, developmental abnormalities, and predisposition to hematological and other solid organ malignancies.Mutations in genes that encode proteins of the FA pathway fail to orchestrate the repair of DNA damage caused by DNA interstrand crosslinks.Zebrafish harbor homologs

A couple of Sylvester matrix equations (CSME) are required to be solved simultaneously in many applications, especially in analysing the stability of control systems.However, there are some situations in which the crisp CSME are not well equipped to deal with the uncertainty problem during the stability analysis of control systems.Thus, where to bu

Social innovations are seen as alternatives to address social and environmental problems facing humanity.However, the term covers a broad range of definitions which can include a variety of initiatives.Based on analytical dimensions of social innovations, this study sought to assess to what extent hybrid willows for sale the emergence of collective

With the increasing attention of modern medicine to natural medicinal agents, Inonotus obliquus (chaga), a macrofungus with remarkable medicinal value, has gradually garnered widespread academic interest.This paper reviews the primary bioactive components of I.obliquus in recent years, including polysaccharides, phenolic compounds, and triterpenoid

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